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For the first time in medical history, biologists have transplanted a functional lab-grown kidney into a live animal. Ever since scientists started dabbling with stem cells 鈥?those super-adaptable pluripotent cells that can transform into virtually any other kind of cell 鈥?theres been hope that well eventually figure out how to grow fully functional replacement organs in the lab. And indeed, regenerative medicine has shown much promise over the years, including successful experiments in which tiny mouse hearts and other organs have been grown. But building stanley cup an approximation of an organ with stem cells is one thing 鈥?actually getting it to work properly in anticipation of transplantation is quite another. Now, researchers working at Massachusetts General Hospital in Boston may have overcome this major hurdle. A team led by Harald Ott took a pre-existing rats kidney and stripped it of all its cells by washing it with a special detergent-like mixture. Once the native cells were stripped away, the biologists were left with a kidney scaffold that they used to create a bioengine stanley cups uk ered graft of the real thing. To create this graft, they introduced stem cells and fostered their re-growth. Specifically, the team re-seeded the kidney scaffolds with epithelial and endothelial cells, and used a pressure gradient to ensure that the right cells were growing in the right places a process that was key to the experiment . Eventually, after fi stanley cup quencher ve days in an incubating chamber, the tissue be |
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